Abstract Library

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#1224 A Randomized Open-label Phase II Study of Everolimus Alone or in Combination with Pasireotide LAR in Advanced, Progressive Pancreatic Neuroendocrine Tumors (pNET): COOPERATE-2 Trial

Introduction: Pasireotide is a somatostatin analog (SSA) that targets somatostatin receptor subtypes 1-3 and 5. An earlier phase I study showed antitumor activity of everolimus+pasireotide LAR (EVE+PAS) in NET.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Kulke M, Ruszniewski P, Van Cutsem E, Valle J, De Herder W,

Keywords: everolimus, pNET, pasireotide LAR,

#1218 Everolimus (EVE) for Advanced, Progressive Pancreatic Neuroendocrine Tumors (pNET): Final Overall Survival (OS) from a Randomized, Double-blind, Placebo (PBO)-Controlled, Multicenter Phase 3 RADIANT-3 Study

Introduction: EVE showed a significant improvement of 6.4 mo in median progression-free survival (PFS) vs PBO (HR 0.35, 95% CI 0.27-0.45; P<0.001) in patients (pts) with pNET in RADIANT-3.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Yao J, Pavel M, Lombard-Bohas C, Van Cutsem E, Lam D,

Keywords: everolimus, pNET, OS,

#336 Overall Survival (OS) Analysis of Sunitinib (SU) After Adjustment for Crossover (CO) in Patients With Pancreatic Neuroendocrine Tumors (NET)

Introduction: A recent phase 3 trial of SU in pancreatic NET showed an improvement in progression-free survival (PFS) and OS. However, the OS benefit was confounded by early CO from placebo (PBO) to SU treatment.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Ishak J, Valle J, Van Cutsem E, Lombard-Bohas C, Ruszniewski P,

Keywords: overall survival, crossover, sunitinib, NET, Rank-Preserving Structural Failure Time model,

#334 Everolimus + Octreotide LAR v. Placebo + Octreotide LAR in Patients With Advanced NET: Results of a Randomized, Double-Blind, Placebo-Controlled, Multicenter Phase 3 Trial (RADIANT-2)

Introduction: Everolimus, an oral inhibitor of mTOR, demonstrated promising antitumor activity in patients with NET as a single agent and in combination with octreotide LAR in two phase 2 studies.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Pavel M, Peeters M, Höersch D, Van Cutsem E, Öberg K,

Keywords: mTOR, everolimus, octreotide LAR, neuroendocrine tumor,